CANCER THERAPY AND RISK OF CONGENITAL MALFORMATIONS IN CHILDREN FATHERED BY MEN TREATED FOR TESTICULAR GERM-CELL CANCER: A NATIONWIDE REGISTER STUDY.

Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study.

BackgroundBecause of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer.Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment.Increased CM ris

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Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies.

Glutathione S-transferases (GSTs) are known to abolish or reduce the activities of intracellular enzymes that help detoxify environmental carcinogens, such Steel as those found in tobacco smoke.It has been suggested that polymorphisms in the GST genes are risk factors for lung cancer, but a large number of studies have reported apparently conflicti

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Positivity bounds on Higgs-Portal dark matter

Abstract We consider the positivity bounds for WIMP scalar dark matter with effective Higgs-portal couplings up to dimension-8 operators.Taking the superposed states for Standard Model Higgs and scalar dark matter, we show that the part of the parameter space for the effective couplings, otherwise unconstrained by phenomenological bounds, is ruled

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